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DESCRIPTION: Amplification of the human protooncogene c-neu occurs in approximately 30% of breast carcinomas and the amplification may be a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of protooncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene.
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SPECIES CROSS-REACTIVITY:
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Human
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| APPLICATIONS/DILUTIONS: |
IF (2.5 ug/ml)
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| SOURCE: |
RBF/DnJ mice were immunized with recombinant human cdc25C fragment corresponding to amino acids 1-258 and fusing the splenocytes with NS-1 mouse myeloma cells. Epitope is known to be between amino acid residues 1-150.
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| FORM/STORAGE: |
100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA. Store at -20º C. Avoid multiple freeze/thaw cycles.
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THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.
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