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Ubiquitin C-Terminal Hydrolase 1

Rabbit Polyclonal Antibody

PRODUCT #: 40-1290

 

DESCRIPTION: Ubiquitin C-terminal hydrolase 1 (UCHL1) has several other names, such as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. The great abundance of this protein in neurons means that it is released from neurons in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
   
SPECIES CROSS-REACTIVITY: Bovine, human, mouse, rat

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/200)
WB (1/1,000)
   
SOURCE: Rabbits were immunized with recombinant full length human UCHL1 purified from E. coli.
   
FORM/STORAGE: 0.1 ml with 50% glycerol, 0.01% sodium azide. 
Store at -20º C.  Avoid multiple freeze/thaw cycles.  Immunoglobulin isotype is IgG1.
   
Reference: Liu Y. et al. Cell 111:209-18 (2002).
   
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.