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Ubiquitin C-Terminal Hydrolase 1

Chicken Polyclonal Antibody

PRODUCT #: 40-1289

 

 

DESCRIPTION: Ubiquitin C-terminal hydrolase 1 is also known as as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5.  It is involved in the regulation of the ubiquitin-mediated protein degradation pathway which is very important because many disease states are associated with defects in this pathway.  Mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease.  Since UCHL1 is heavily expressed in neurons, antibodies to UCHL1 can be used to identify neurons in histological sections and in tissue culture.  The great abundance of this protein in neurons means that it is released from neurons in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
   
SPECIES CROSS-REACTIVITY: Bovine, human, mouse, rat

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/200)
WB (1/2,000)
   
SOURCE: Chickens were immunized with full length recombinant human UCHL1.
   
FORM/ STORAGE: 0.1 ml with 50% glycerol, 0.01% sodium azide. Store at -20º C.  Avoid multiple freeze/thaw cycles. Immunoglobulin isotype is IgY.
   
Reference: Liu Y, et al. Cell 111:209-18 (2002).
   
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.