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Stearoyl-CoA Desaturase (Clone CD.E10)

Mouse Monoclonal Antibody

PRODUCT #: 31-1019

 

DESCRIPTION:

Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355aa, rat 358aa; ~37 KDa) is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. The SCD-1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD-1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders.

 

SPECIES CROSS-REACTIVITY: Human, mouse
APPLICATIONS/DILUTIONS:    

WB (1:100-250)

ELISA (1-2000-5000)

 

SOURCE: Mice were immunized with recombinant SCD1 protein.
FORM/STORAGE: 50 ug (0.5 mg/ml affinity purified IgG2b in PBS with 50% glycerol, 1.0 mg/ml BSA and 0.01% sodium azide). Store at -20o C. Avoid multiple freeze/thaw cycles.

 

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.