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Myrisolated Alanine Rich C-Kinase Substrate (MARCKS)

Rabbit Polyclonal Antibody

PRODUCT #: 40-1268

 

 

DESCRIPTION: Myristolyated alanine rich C-kinase substrate (MARCKS) is a major protein of the brain, and it is concentrated in the synapses of the neurons. It appears to function in synaptic vesicle cycling and has been shown to bind both actin and calmodulin in vitro. MARCKS belongs to a family of proteins with similar actin and calmodulin binding properties. Deletion of the MARCKS gene in mice results in embryonic brain defects and death.
   
SPECIES CROSS-REACTIVITY: Human, mouse, rat

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/500)
WB (1/5,000)
   
SOURCE: Rabbits were immunized with full length recombinant MARCKS expressed in E. coli.
   
FORM/STORAGE: 0.1 ml with 50% glycerol, 0.01% sodium azide. Store at -20º C.  Avoid multiple freeze/thaw cycles.
   
Reference: Hartwig JH et al. Nature 356: 618-622 (1992)
Blackshear PJ. J. Biol. Chem. 268: 1501-1504 (1993).
Stumpo DJ, et al. Proc. Nat. Acad. Sci. 92; 944-948 (1995)
   
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.