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Microtubule Associated Protein 2 (MAP2)

Chicken Polyclonal Antibody

PRODUCT #: 40-1269

 

DESCRIPTION: Microtubles are 25nm diameter protein rods found in most kinds of eukarytic cells.  They are polymerized from a dimeric subunit made of one α (alpha) subunit and one β (beta) tubulin subunit.  Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5.  MAP2 forms derive from a single gene by alternate transcription, and share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein t.  MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells.  Antibodies to MAP2 are therefore excellent markers on neuronal cells, their perikarya and neuronal dendrites. In contrast, t is found predominantly in neuronal axons.
   
SPECIES CROSS-REACTIVITY: Bovine, human, mouse, rat

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/1,000)
WB (1/10,000)
   
SOURCE: Chickens were immunized with purified bovine MAP2.
   
FORM/ STORAGE: 0.05 ml with 50% glycerol, 0.01% sodium azide. Store at -20º C.  Avoid multiple freeze/thaw cycles.  Immunoglobulin isotype is IgY.
   
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.