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Matrix Metalloproteinase MMP2 (Clone 2C1)

Mouse Monoclonal Antibody

PRODUCT #: 45-6804

 

DESCRIPTION: Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans.  In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an approximately 10 kDa segment from the N-terminus and they are inhibited by tissue inhibitor of metalloproteinases (TIMP).  These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis.
 

SPECIES CROSS-REACTIVITY:

Rat
 

APPLICATIONS/DILUTIONS:

FFPE (2.5 ug/ml)
 

SOURCE:

Mice were immunized with recombinant rat MMP-2 protein and fusing the splenocytes with SP2/0-NS1mouse myeloma cells.
 

FORM/STORAGE:

100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA. Store at -20º C. Avoid multiple freeze/thaw cycles.

 

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.